Reading the PK/PD sections

When you select a compound in the timeline, the inspector shows several PK/PD-specific sections under the standard header. They're laid out top-to-bottom in roughly chronological order (what happens first → what happens last). This page walks each one.

Earlier versions of Lab opened a separate "PK/PD drawer" overlay. The drawer is gone — these sections now live inline in the inspector itself, so you can read PK/PD detail without losing your timeline context. Enzyme detail still gets its own dedicated view (see below).

Biological Effects

Every PD effect the compound exerts, with the receptor or target it binds and the response it produces. Each row carries citation pills — green for literature-anchored magnitudes, blue for calibrations.

Click any row to expand: affinity (Ki / Kd), response time constant (τ), and the full source list for that effect.

Active interactions

If the compound is participating in any interactions on the current timeline, they appear here in severity order. A "Find more synergy" link surfaces beneficial pairings you haven't added yet.

Subject impact

How your physiology shifts the drug's behavior — sex, age, conditions, and bloodwork-derived multipliers on absorption, distribution, and clearance.

Clearance

Hepatic, renal, and biliary breakdown of where the drug goes. Each enzyme involved is a clickable chip that opens the enzyme detail panel for that enzyme.

Effects on other drugs

What enzymes this compound inhibits or induces, and the magnitude. Useful for predicting why your other compounds might be behaving unexpectedly.

Absorption + binding

• Bioavailability — % of dose that reaches systemic circulation
• Protein binding % — free vs. bound drug. Free fraction is what causes effects.
• Half-life — time for concentration to halve
• Tmax / Cmax — time-to-peak and peak concentration

References

Collapsed by default. Numbered entries match every pill across every section above. Click any pill above to auto-expand and scroll to the matching entry.

The enzyme detail panel

When you click an enzyme chip in the Clearance section (or anywhere else an enzyme is named), a dedicated enzyme detail panel replaces the inspector view. It shows:

• The enzyme's current activity multiplier (1.00 = your baseline) at the playhead
• A sparkline showing how it's evolved across the simulation
• "How it's composed" — every factor pushing the activity above or below 1.00
• "Active modulators" — every timeline item currently inhibiting or inducing this enzyme, with click-through to those items

Use the back arrow to return to the inspector view.